Interactions of Isophorone Derivatives with DNA: Spectroscopic Studies |
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| Authors: | Marco Deiana Katarzyna Matczyszyn Julien Massin Joanna Olesiak-Banska Chantal Andraud Marek Samoc |
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| Institution: | 1. Advanced Materials Engineering and Modelling Group, Faculty of Chemistry, Wroclaw University of Technology, Wyb. Wyspianskiego 27, 50–370, Wroclaw, Poland.; 2. Laboratoire de Chimie, CNRS UMR 5182, Ecole Normale Supérieure de Lyon, Université Lyon 1, Lyon, France.; University of Quebect at Trois-Rivieres, CANADA, |
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| Abstract: | Interactions of three new isophorone derivatives, Isoa Isob and Isoc with salmon testes DNA have been investigated using UV-Vis, fluorescence and circular dichroism spectroscopic methods. All the studied compounds interact with DNA through intercalative binding mode. The stoichiometry of the isophorone/DNA adducts was found to be 1:1. The fluorescence quenching data revealed a binding interaction with the base pairs of DNA. The CD data indicate that all the investigated isophorones induce DNA modifications. |
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