Quantitative transdermal behavior of pellitorine from Anacyclus pyrethrum extract |
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| Institution: | 1. Drug Quality and Registration (DruQuaR) Group, Faculty of Pharmaceutical Sciences, Ghent University, Ottergemsesteenweg 460, B-9000 Ghent, Belgium;2. Department of Plastic and Reconstructive Surgery, University Hospital Ghent, De Pintelaan 185, B-9000 Ghent, Belgium;3. Department of Comparative Physiology and Biometrics, Faculty of Veterinary Medicine, Ghent University, Salisburylaan 133, B-9820 Merelbeke, Belgium;1. Department of Chemical Engineering and Environmental Technology, University of Valladolid, Dr. Mergelina s/n, 47011 Valladolid, Spain;2. IPICyT, Instituto Potosino de Investigación Científica y Tecnológica, División de Ciencias Ambientales, Camino a la Presa San José No. 2055, C.P. 78216 San Luis Potosí, Mexico;1. Biochemistry Department, Babcock University Ilishan-Remo, Ikeja, PMB 21244, Nigeria;2. Dr. Panjwani Center for Molecular Medicine and Drug Research (PCMD), International Center for Chemical and Biological Sciences, University of Karachi, Karachi, 75270, Pakistan;3. HEJ Research Institute of Chemistry, University of Karachi, Karachi, 75270, Pakistan;4. Department of Biochemistry and Molecular Biology, Obafemi Awolowo University, Ile Ife, Nigeria;5. Biology Department, Adventist University of West Africa, Monrovia, Liberia;1. Radiation and Space Materials Laboratory, Tomsk State University of Control Systems and Radio-electronics, Tomsk, Tomsk Region 634050, Russia;2. Space Materials Laboratory, Amur State University, Blagoveshchensk, Amur Region 675027, Russia |
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| Abstract: | The plant Anacyclus pyrethrum (AP) consists of several N-alkylamides with pellitorine as main constituent. AP extracts are known to be biologically active and some products for topical administration containing AP plant extracts are already commercially available with functional cosmeceutical claims. However, no transdermal data for pellitorine are currently available. Therefore, our general goal was to investigate the local skin pharmacokinetics of the plant N-alkylamide pellitorine using a Franz diffusion cell set-up. Two different forms were applied on human skin: purified pellitorine and the AP extract. Our study demonstrated that pellitorine is able to cross the stratum corneum and the subsequent skin layers. A significantly higher permeability coefficient was observed when the AP extract (Kp = 2.3 × 10−4 cm/h) was administered, compared to purified pellitorine (Kp = 1.1 × 10−4 cm/h). With the obtained pellitorine concentrations in the skin layers and the receptor fluid, it is concluded that local and systemic effects can be expected after topical application. Due to these findings and as a regulatory consequence, products containing reasonable concentrations of pellitorine are recommended to be classified as a medicinal product. |
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| Keywords: | Pellitorine Franz diffusion cells Transdermal Human skin |
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