Efficacy of natural diosgenin on cardiovascular risk,insulin secretion,and beta cells in streptozotocin (STZ)-induced diabetic rats |
| |
| Affiliation: | 1. Department of Biotechnology, Periyar Maniammai University, Vallam 613403, Tamil Nadu, India;2. Anbil Dharmalingam Agricultural College and Research Institute, Tamilnadu Agricultural University, Trichy 630102, India;1. College of Chinese Medicine Materials, Jilin Agricultural University, Changchun 130118, China;2. The First Affiliated Hospital of Changchun University of Traditional Medicine, Changchun University of Traditional Chinese Medicine, Changchun 130021, China;3. Development Center of Traditional Chinese Medicine and Bioengineering, Changchun University of Traditional Chinese Medicine, Changchun 130117, China;1. Biometry and Nutrition Group, Agharkar Research Institute, Pune 411 004, India;2. National Center for Cell Science, University of Pune, Pune 411 007, India;3. Dept. of Botany, University of Pune, Pune 411 007, India;1. Department of Biochemistry, Centre for Biological Science, K.S. Rangasamy College of Arts and Science, Thokkavadi, Tiruchengode, Tamil Nadu, India;2. Department of Biotechnology, K.S. Rangasamy College of Technology, Thokkavadi, Tiruchengode, Tamil Nadu, India;3. Department of Biosciences, Kristu Jayanthi College, Bangalore, Karnataka, India;4. PG and Research Department of Zoology, C. Abdul Hakeem College, Melvisharam, Tamil Nadu, India;5. Department of Zoology, Thriruvalluvar University, Serkkadu, Vellore, Tamil Nadu, India;1. Department of Obstetrics, Second Hospital of Tianjin Medical University, Tianjin 300211, China;2. Neonatal Department, Second Hospital of Tianjin Medical University, Tianjin 300211, China |
| |
| Abstract: | Costus igneus, has been prescribed for the treatment of diabetic mellitus in India for several years. The aim of this study is to investigate the effects of plant derived diosgenin on cardiovascular risk, insulin secretion, and pancreatic composition through electron microscopical studies of normal and diabetic rats. Diosgenin at a dose of 5 or 10 mg/kg per body weight (bw) was orally administered as a single dose per day to diabetic induced rats for a period of 30 days. The effect of diosgenin on blood glucose, HbA1c, PT, APTT, Oxy-LDL, serum lipid profile, electron microscopical studies of pancreas, antioxidant enzymes (in liver, kidney, pancreas) and hepatoprotective enzymes in plasma and liver were measured in normal and diabetic rats. The results showed that fasting blood glucose, PT, APTT, Oxy-LDL, TC, TG, LDL, ALT, AST, ALP, glucose-6-phosphatase, fructose-1,6-bisphosphatase and LPO levels were significantly (p < 0.05) increased, whereas HDL, SOD, CAT, GSH and the glycolytic enzyme glucokinase levels were significantly (p < 0.05) decreased in the diabetes induced rats and these levels were significantly (p < 0.05) reversed back to normal in diabetes induced rats after 30 days of treatment with diosgenin. Electron microscopical studies of the pancreas revealed that the number of beta cells and insulin granules were increased in streptozotocin (STZ) induced diabetic rats after 30 days of treatment with diosgenin. In conclusion, the data obtained from the present study strongly indicate that diosgenin has potential effects on cardiovascular risk, insulin secretion and beta cell regeneration in STZ induced diabetic rats, these results could be useful for new drug development to fight diabetes and its related cardiovascular diseases. |
| |
| Keywords: | Diosgenin Oxy-LDL Cardiovascular Insulin |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
