Gastroprotective effect of epoxy clerodane diterpene isolated from Tinospora cordifolia Miers (Guduchi) on indomethacin-induced gastric ulcer in rats |
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| Affiliation: | 1. Department of Veterinary Physiology, College of Veterinary Medicine, Chonbuk National University, Biosafety Research Institute, 664-14, 1GA, Duckjin-Dong, Duckjin-Gu, Jeonju City, Jeollabuk-Do 561-756, Republic of Korea;2. Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai 600 034, Tamil Nadu, India;3. Department of Plant Biology and Biotechnology, Loyola College, Chennai 600 034, Tamil Nadu, India;4. Department of Botany and Microbiology, College of Science, King Saud University, PO Box No. 2455, Riyadh 11451, Saudi Arabia;1. Animal Production Department, Faculty of Agriculture, Tanta University, 31527, Tanta, Egypt;2. Faculty of Desert Agriculture, King Salman International University, South Sinai, Egypt;3. Microbiology, Botany Department, Faculty of Agriculture, Tanta University, 31527, Tanta, Egypt;4. Animal and Fish Production Department, Faculty of Agriculture- Saba Basha, Alexandria University, Egypt;5. National Institute of Oceanography and Fisheries, NIOF, Cairo, Egypt;6. Animal and Fish Production Department, Faculty of Agriculture - El Shatby, Alexandria University, Egypt;7. Animal Production Research Institute, Agriculture Research Center, Dokki, Giza, Egypt;8. Institute for Tropical Biodiversity and Sustainable Development, Universiti Malaysia Terengganu, 21030, Kuala Nerus, Terengganu, Malaysia;9. Institute of Marine Biotechnology, Universiti Malaysia Terengganu, 21030, Kuala Nerus, Terengganu, Malaysia;10. The Center for Applied Research on the Environment and Sustainability, The American University in Cairo, 11835, Cairo, Egypt;11. Department of Engineering Hydrology, RWTH Aachen University, Aachen, Germany;12. Department of Pharmacology, Faculty of Veterinary Medicine, Matrouh University, Egypt;13. Animal Production Department, Faculty of Agriculture, Kafrelsheikh University, Kafr El-Sheikh, 33516, Egypt;1. Department of Veterinary Physiology, College of Veterinary Medicine, Chonbuk National University, Biosafety Research Institute, 664-14, 1GA, Duckjin-Dong, Duckjin-Gu, Jeonju City, Jeollabuk-Do 561-756, Republic of Korea;2. Molecular Biology Research Lab, Department of Food Science and Nutrition, College of Food and Agricultural Science, King Saud University, Riyadh 11451, Saudi Arabia;3. Division of Ethnopharmacology, Entomology Research Institute, Loyola College, Chennai 600 034, Tamil Nadu, India;4. Grassland and Forage Division, National Institute of Animal Science, RDA, Seonghwan-Eup, Cheonan-Si, Chungnam 330-801, Republic of Korea;1. Academy of Scientific and Innovative Research, New Delhi, India;2. Natural Product Chemistry and Process Development Division, CSIR-Institute of Himalayan Bioresource Technology, Palampur, Himachal Pradesh 176 061, India;3. Regulatory Research Centre, Department of Biotechnology, CSIR-Institute of Himalayan Bioresource, Palampur, Himachal Pradesh, 176 061, India |
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| Abstract: | The present study evaluated the gastroprotective effect of epoxy clerodane diterpene (ECD), isolated from Tinospora cordifolia on indomethacin-induced gastric ulcer in rats. Administration of indomethacin exhibits extreme levels of ulcer index (UI) and myeloperoxidase (MPO) activity. Indomethacin down regulated PGE2, anti-inflammatory cytokines (IL-4, IL-10) and pro-angiogenic factors (VEGF and EGF). The ECD pretreatment considerably increased the levels of PGE2, anti-inflammatory cytokines and pro-angiogenic factors. The ulcer-healing activity of ECD was inhibited by pre-administration of the specific COX-1 inhibitor (SC560) and nonspecific NOS inhibitor (l-NAME), which indicates the involvement of PGE2 and NOS in ECD induced ulcer healing activity. These findings suggest that ECD exerts its antiulcer activity by reinforcement of defensive elements and diminishing the offensive elements. |
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| Keywords: | Antiulcer Ulcer index Epoxy clerodane diterpene Gastric ulcer |
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