Diosgenin inhibits the migration of human breast cancer MDA-MB-231 cells by suppressing Vav2 activity |
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| Institution: | 1. College of Chinese Medicine Materials, Jilin Agricultural University, Changchun 130118, China;2. The First Affiliated Hospital of Changchun University of Traditional Medicine, Changchun University of Traditional Chinese Medicine, Changchun 130021, China;3. Development Center of Traditional Chinese Medicine and Bioengineering, Changchun University of Traditional Chinese Medicine, Changchun 130117, China;1. Molecular Bioprospection Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India;2. Medicinal Chemistry Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India;3. Molecular and Structural Biology Department, CSIR-Central Institute of Medicinal and Aromatic Plants, Lucknow 226015, India;4. Department of Chemistry, University of Ilorin, Ilorin, Nigeria;5. Organic Chemistry Unit, Department of Chemistry, University of Ibadan, Ibadan, Nigeria;1. Department of Obstetrics, Second Hospital of Tianjin Medical University, Tianjin 300211, China;2. Neonatal Department, Second Hospital of Tianjin Medical University, Tianjin 300211, China;1. CSIR-Central Institute of Medicinal and Aromatic Plants (CSIR-CIMAP), Kukrail Picnic Spot Road, P.O. CIMAP, Lucknow 226015, India;2. CSIR-Central Drug Research Institute (CSIR-CDRI), B.S. 10/1, Sector 10, Jankipuram Extension, Sitapur Road, Lucknow 226031, India;3. Department of Chemistry, University of Ilorin, Ilorin, Nigeria;4. Organic Chemistry Unit, Department of Chemistry, University of Ibadan, Ibadan, Nigeria;1. Department of Biochemistry, Centre for Biological Science, K.S. Rangasamy College of Arts and Science, Thokkavadi, Tiruchengode, Tamil Nadu, India;2. Department of Biotechnology, K.S. Rangasamy College of Technology, Thokkavadi, Tiruchengode, Tamil Nadu, India;3. Department of Biosciences, Kristu Jayanthi College, Bangalore, Karnataka, India;4. PG and Research Department of Zoology, C. Abdul Hakeem College, Melvisharam, Tamil Nadu, India;5. Department of Zoology, Thriruvalluvar University, Serkkadu, Vellore, Tamil Nadu, India;1. Department of Biotechnology, Periyar Maniammai University, Vallam 613403, Tamil Nadu, India;2. Anbil Dharmalingam Agricultural College and Research Institute, Tamilnadu Agricultural University, Trichy 630102, India |
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| Abstract: | Diosgenin, a naturally occurring steroidal saponin, possess tumor therapeutic potential. However, the effect of diosgenin on cancer metastasis remains poorly understood. In this study, we performed in vitro experiments to investigate the inhibitory activity of diosgenin on human breast cancer MDA-MB-231 cell migration, and reveal the possible mechanism. Diosgenin caused a marked inhibition of cell migration in MDA-MB-231 cell by transwell assay. In addition, diosgenin significantly impacted MDA-MB-231 cell migratory behavior under real-time observation. We also found diosgenin significantly inhibited actin polymerization, Vav2 phosphorylation and Cdc42 activation, which might be, at least in part, attributed to the anti-metastatic potential of diosgenin. These findings reveal a new therapeutic potential of diosgenin for human breast cancer metastasis therapy. |
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| Keywords: | Diosgenin Breast cancer Migration Actin polymerization Vav2 Cdc42 |
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