Antidyslipidemic and antioxidant activity of an unusual amino acid (2-amino-5-hydroxyhexanoic acid) isolated from the seeds of Crotalaria juncea |
| |
| Institution: | 1. Key Laboratory of Bioactive Substances and Resources Utilization of Chinese Herbal Medicine, Ministry of Education, Institute of Medicinal Plant Development, Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing 100193, China;2. Guangxi Botanical Garden of Medicinal Plants, Nanning 530023, China;3. Center of Research and Development on Life Sciences and Environment Sciences, Harbin University of Commerce, Harbin 150076, China;4. Department of Neurosurgery, Shenzhen Second People''s Hospital, Shenzhen 518035, China |
| |
| Abstract: | In continuation of our drug discovery programme on Indian medicinal plants, we isolated an unusual amino acid, i.e. 2-amino-5-hydroxyhexanoic acid (1) from the seeds of Crotalaria juncea. The 2-amino-5-hydroxyhexanoic acid (1) showed dose dependent lipid lowering activity in the in vivo experiments and also showed good in vitro antioxidant activity. The cyclized compound, 3-amino-6-methyltetrahydro-2H-pyran-2-one (2) showed better lipid lowering and antioxidant profile than the parent compound 1. |
| |
| Keywords: | Antidyslipidemic activity Triton model Antioxidant activity |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
