Hypoglycemic and hypolipidemic effects of oxymatrine in high-fat diet and streptozotocin-induced diabetic rats |
| |
| Institution: | 1. Institute of Natural Medicine, University of Toyama, 2630-Sugitani, Toyama 930-0194, Japan;2. Research Unit for Development of Chemical Engineering Processes, Indonesian Institute of Sciences (LIPI), Jl. Jogja-Wonosari Km. 32, Playen, Gunungkidul, Yogyakarta, 55861, Indonesia;3. Faculty of Pharmaceutical Sciences, Tokushima Bunri University, Yamashiro-cho, Tokushima 770-8514, Japan;1. Department of Pharmacology, Ningxia Medical University, Yinchuan 750004, China;2. Department of Neurology, General Hospital of Ningxia Medical University, Yinchuan 750004, China;3. Medical Sci-tech Research Center, Ningxia Medical University, Yinchuan 750004, China;4. Key Laboratory of Hui Ethnic Medicine Modernization, Ministry of Education, Ningxia Medical University, Yinchuan 750004, China;5. Ningxia Key Laboratory of Craniocerebral Diseases of Ningxia Hui Autonomous Region, Ningxia Medical University, Yinchuan 750004, China;6. College of Nursing, Ningxia Medical University, Yinchuan 750004, China;7. Ningxia Hui Medicine Modern Engineering Research Center and Collaborative Innovation Center, Ningxia Medical University, Yinchuan 750004, China |
| |
| Abstract: | Oxymatrine, a quinolizidine alkaloid, has been widely used for the treatment of hepatitis. In this study, we investigated the hypoglycemic and hypolipidemic effects and new pharmacological activities of oxymatrine, in a high-fat diet and streptozotocin (STZ)-induced diabetic rats. The results demonstrated that oxymatrine could significantly decrease fasting blood glucose, glycosylated hemoglobin (GHb), food and water intake, non-esterified fatty acid (NEFA), total cholesterol (TC), triglyceride (TG), low density lipoprotein cholesterol levels (LDL-c), and increase serum insulin, liver and muscle glycogen, high density lipoprotein cholesterol (HDL-c), glucagon-like peptide-1 (GLP-1) and muscle glucose transporter-4 (GLUT-4) content in diabetic rats. The results of the histological examinations of the pancreas and liver show that oxymatrine protected the islet architecture and prevented disordered structure of the liver. This study displays that oxymatrine can alleviate hyperglycemia and hyperlipemia in a high-fat diet and STZ-induced diabetic rats might by improving insulin secretion and sensitivity. |
| |
| Keywords: | Oxymatrine Diabetes Insulin resistance Hypoglycemic Hypolipidemic |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
