Plasma zinc in adults with cystic fibrosis: Correlations with clinical outcomes |
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| Affiliation: | 1. Department of Nutrition, University of Montreal, Montreal, Quebec, Canada H3C 3J7;2. Cystic Fibrosis Clinic, Centre hospitalier de l’Université de Montréal (CHUM) – Hôtel-Dieu, Montréal, Québec, Canada H2W 1T8;3. Institut de Recherches Cliniques de Montréal, Platform for Research on Obesity, Metabolism, and Diabetes (PROMD), Montréal, Québec, Canada H2W 1R7;4. Gastroenterology, Hepatology and Nutrition Unit, CHU Sainte-Justine Research Center, Montréal, Québec, Canada H3T 1C5;1. Department of Pediatrics, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea;2. Department of Occupational and Environmental Medicine, Ulsan University Hospital, University of Ulsan College of Medicine, Ulsan, South Korea;1. Department of Computer Science, Royal Holloway University of London, United Kingdom;2. Institute of Mathematics of the Romanian Academy, Research group of the project ID-3-0439, Romania;1. School of Public Health XinXiang Medical University XinXiang, China 453003;2. Center for Environmental Medicine, Asthma and Lung Biology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA;3. Environmental Public Health Division, National Health and Environmental Effects Research Laboratory, U.S. EPA, Chapel Hill, NC 27514, USA;1. Institute of Structural Macrokinetics and Materials Science, Russian Academy of Sciences, 142432 Chernogolovka, Moscow Region, Russian Federation;2. N. N. Semenov Institute of Chemical Physics, Russian Academy of Sciences, 119991 Moscow, Russian Federation;1. Department of Radiology, Hebrew University Hadassah Medical Center, Jerusalem, Israel;2. Department of Pediatrics, Hebrew University Hadassah Medical Center, Jerusalem, Israel;1. Cardiovascular Center, the First Hospital of Jilin University, Changchun, China;2. Department of Pediatrics, University of Louisville, Louisville, KY, USA;3. Department of Nephrology, the Second Hospital of Jilin University, Changchun, China;4. Department of Internal Medicine, Marshall University Joan C. Edwards School of Medicine, Huntington, WV, USA;5. Wendy Novak Diabetes Care Center, University of Louisville, Louisville, KY, USA;6. Department of Chemistry, University of Louisville, Louisville, KY, USA |
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| Abstract: | BackgroundZinc status has been previously documented in cystic fibrosis (CF) infants, children and adolescents. However, despite the increasing life expectancy observed in CF populations, data regarding zinc status of CF adults are surprisingly lacking. The objectives of this study were to (1) characterize zinc status and (2) explore associations between zinc status and clinical outcomes of CF adult patients.MethodsA retrospective chart review was performed for patients who had their plasma zinc measured between 2009 and 2012. Data included demographics, clinical characteristics, biochemical parameters and co-morbid conditions.ResultsA total of 304 CF patients were included in the study. These patients displayed a good nutritional status (mean BMI ± SD: 22.7 ± 3.5) and moderate lung disease (mean FEV1 ± SD: 66.3 ± 22.2). Low plasma zinc concentration (<9.2 μmol/L) was found in 68 out of 304 CF patients (22.4%). Compared to patients with normal zinc, those with low zinc had significantly lower forced vital capacity and forced expiratory volume in one second. 72% of CF adults with low zinc suffered from bone disease (vs 49% with normal zinc, p = 0.037) and 79% had impaired glycemic status (vs 58%, p = 0.016). Accordingly, negative correlations were found between plasma zinc and glucose (r = −0.139, p = 0.0001), HbA1c (r = −0.237, p = 0.0001) and fructosamine (r = −0.134, p = 0.034). In multiple linear regression, albumin and glycemic status were significant predictors of plasma zinc.ConclusionOur data indicated that nearly one quarter of CF adults with good nutritional status and moderate lung disease had low plasma zinc concentration and that low zinc status was associated with worse clinical outcomes. |
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| Keywords: | Zinc Cystic fibrosis Retrospective study |
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