Potential for daily supplementation of n-3 fatty acids to reverse symptoms of dry eye in mice |
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| Affiliation: | 1. School of Life and Environmental Science, Azabu University, 1-17-71, Fuchinobe, Sagamihara, Kanagawa 252-5201, Japan;2. Human Life Science Research and Development Center, Nippon Suisan Kaisha Ltd., 2-6-2, Otemachi, Chiyoda-ku, Tokyo 100-8686, Japan;1. Ophthalmos Research and Educational Institute, Morfou 48, Egkomi, 2417 Nicosia, Cyprus;2. Molecular Medicine Research Centre and Laboratory of Molecular and Medical Genetics, Department of Biological Sciences, University of Cyprus, Kallipoleos 75, 1678 Nicosia, Cyprus;3. Developmental and Functional Genetics Group, The Cyprus Institute of Neurology and Genetics, 1683 Nicosia, Cyprus;1. Graduate Program in Molecular and Cellular Biology, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil;2. Oxidative Stress Laboratory, Department of Biophysics, Institute of Biosciences, Federal University of Rio Grande do Sul, Porto Alegre, RS, Brazil;1. Laser Eye Clinic, Noida 201301, India;2. Department of Pathology, Santosh Medical College and Hospital, Ghaziabad 201301, India;3. Department of Ophthalmology, Rotary Eye Hospital, Maranda, Palampur 176102, India;4. Department of Microbiology, Narayan Medical College, Sasaram, India |
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| Abstract: | The purpose of this study was to determine the change in tear volume, as a predominant symptom of dry eye syndrome, in dietary n-3 fatty acid deficient mice compared with n-3 fatty acid adequate mice. The tear volume in n-3 fatty acid deficient mice was significantly lower than that in n-3 fatty acid adequate mice. In addition, the concentration of n-3 fatty acid in the lacrimal and meibomian glands, which affects the production of tears, was markedly decreased compared with n-3 fatty acid adequate mice. However, the tear volume recovered almost completely after one week of continuous administration of fish oil containing EPA and DHA in n-3 fatty acid deficient mice. Also, the concentration of DHA in the meibomian gland of n-3 fatty acid deficient group recovered to approximately 80% more than that of n-3 fatty acid adequate group. These results suggested that dietary n-3 fatty acids deficiency showed reversible dry eye syndrome, and that n-3 fatty acids have an important role in the production of tears. |
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| Keywords: | n-3 Fatty acid Fish oil Dry eye syndrome Mice |
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