Synthesis of licochalcone analogues with increased anti-inflammatory activity |
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| Affiliation: | 1. Department of Traditional Chinese Medicine Chemical, Shenyang Pharmaceutical University, Shenyang 110016, China;2. Guiyang College of Traditional Chinese Medicine, Guiyang 550002, China;3. Guizhou Medical University, Guizhou 550025, China;4. Key Laboratory of Structure-based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, China;1. Shaanxi Key Labotory of Natural Products & Chemical Biology, Shaanxi Engineering Center of Bioresource Chemistry & Sustainable Utilization, College of Chemistry & Pharmacy, Northwest A&F University, Yangling 712100, PR China;2. Faculty of Basic Science, Vietnam National University of Forestry Southern Campus, Trang Bom, DongNai, Viet Nam;3. Institute of Scientific Research and Technological Development, Thu Dau Mot University, Binh Duong, Viet Nam. |
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| Abstract: | Licohalcones have been reported to have various biological activities. However, most of licochalcones also showed cytotoxicity even though their versitile utilities. Licochalcones B and D, which have common substituents at aromatic ring B, are targeted to modify the structure at aromatic ring A for inflammatory studies. Licochalcone derivatives (1–6) thus prepared are compared for their suppression ability of nitric oxide (NO) production and showed 9.94, 4.72, 10.1, 4.85, 2.37 and 4.95 μM of IC50 values, respectively. |
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| Keywords: | Licohalcone B Licohalcone D [3,3]-Sigmatropic rearrangement |
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