Oxidative damage and the Nrf2-ARE pathway in neurodegenerative diseases |
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| Affiliation: | 1. School of Pharmacy, University of Wisconsin–Madison, WI 53705, USA;2. Waisman Center, University of Wisconsin–Madison, WI 53705, USA;3. Molecular and Environmental Toxicology Center, University of Wisconsin–Madison, WI 53705, USA;4. Center of Neuroscience, University of Wisconsin–Madison, WI 53705, USA |
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| Abstract: | Oxidative damage contributes to pathogenesis in many neurodegenerative diseases. As the indicator and regulator of oxidative stress, the Nrf2-ARE pathway has been shown dynamic changes and examined for its neuroprotective role in many cases. In this review, we summarize the progress of the Nrf2-ARE pathway in combating toxicity induced from typical misfolded protein aggregates in neurodegenerative diseases, and specifically the effects on the clearance of protein aggregates. This article is part of a Special Issue entitled: Misfolded Proteins, Mitochondrial Dysfunction, and Neurodegenerative Diseases. |
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