Is chromium pharmacologically relevant? |
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| Institution: | 1. Department of Human Nutrition, Seitoku University Graduate School, Chiba, Japan;1. Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil;2. Department of Pathology, School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, Brazil;1. Food Technology Department, Faculty of Engineering, BINUS University, Alam Sutra Campus, Tangerang, Indonesia;2. SEAMEO RECFON University of Indonesia, Salemba Raya 6, Jakarta, Indonesia;3. Faculty of Medicine, Indonesian Christian University, Jl. Mayjen Sutoyo Cawang, Jakarta 13630, Indonesia;4. Department of Public Health, Gunma University, Graduate School of Medicine, 39-22 Showa-machi 3-chome, Maebashi, Gunma 371-8511, Japan |
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| Abstract: | Recent research, combined with reanalysis of previous results, has revealed that chromium can no longer be considered an essential trace element. Clinical studies are ambiguous at best as to whether Cr has a pharmacological effect in humans. Observed effects of Cr on rodent models of insulin resistance and diabetes are best interpreted in terms of a pharmacological role for Cr. Studies on the effects of Cr on rat models of diabetes are reviewed herein and suggest Cr increases insulin sensitivity in peripheral tissues of the rodent models. The lack of effects in human studies may stem from humans receiving a comparably smaller dose than the rodent models. However, given the different responses to Cr in the rodent models, humans could potentially have different responses to Cr. |
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| Keywords: | Chromium Humans Rats Insulin resistance Type 2 diabetes |
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