Protective effect of omega-3 fatty acid against mercury chloride intoxication in mice |
| |
| Institution: | 1. Department of Biochemistry, Faculty of Veterinary Medicine, Kafkas University, 36100 Kars, Turkey;2. Department of Molecular Biology and Genetic, Faculty of Arts and Science, Kafkas University, 36100 Kars, Turkey;3. Department of Pathology, Faculty of Veterinary Medicine, Kafkas University, 36100 Kars, Turkey;4. Atatürk Health Services Vocational School, Kafkas University, 36100 Kars, Turkey;1. Institute of Nutrition and Food Technology (INTA), University of Chile, Santiago, Chile;2. Universidad de San Simón, Cochabamba, Bolivia;1. Engineering Ceramic Centre, Korea Institute of Ceramic Engineering and Technology, Icheon, Gyeonggi-do 467-843, Republic of Korea;2. CAE & Materials Research Team, Central Advanced Research and Engineering Institute, Hyundai & Kia Corporate Research and Development Division, Gyeonggi-do 445-706, Republic of Korea;3. Hyundai Hysco, Research and Development Team, Chungcheongnam-do 343-831, Republic of Korea;1. Food Science Technology College of Henan Agricultural University, Zhengzhou 450002, China;2. College of Public Health, Zhengzhou University, Zhengzhou 450001, China;1. Department of General and Vascular Surgery, Medical University of Silesia, Poland;2. Department of Inorganic Chemistry, University of Silesia, Poland;3. Department of Pathophysiology, Medical University of Silesia, Poland;4. Department of Biophysics, Medical University of Silesia, Katowice, Poland;1. Department of Environmental Studies, Institute of Graduate Studies and Research, Alexandria University, Alexandria, Egypt;2. Department of Pest Control and Environmental Protection, Faculty of Agriculture, Damanhour University, Damanhour, Egypt |
| |
| Abstract: | The aim of this study was to investigate the protective effect of omega-3 fatty acid in HgCI2 toxicity in mice. Levels of malondialdehyde (MDA), reduced glutathione (GSH), nitric oxide (NO) and total sialic acid (TSA), and histopathological changes in selected organs were evaluated. Twenty-eight mice were equally divided into 4 groups, namely Groups I–IV. Group I animals received intraperitoneal (ip) injection of physiological saline solution; Group II animals received ip injection of 0.4 mg/kg/day HgCI2; Group III animals received ip injection of 0.4 mg/kg/day HgCI2 in addition to subcutaneous (sc) injection of 0.5 g/kg/day omega-3 fatty acid; and Group IV animals received sc injection of 0.5 g/kg/day omega-3 fatty acid. All treatments lasted 7 days. The levels of MDA, NO and TSA were significantly higher in Group II and lower in Groups III and IV as compared to the Group I. GSH level was the highest in Group IV. In histopathology, severe degeneration in liver and kidney was observed in Group II animals. These degrading changes were seen to be reduced greatly in Group III animals. The results suggested that omega-3 fatty acid might attenuate HgCI2-induced toxicity by improving antioxidant status and acute phase response in mice. |
| |
| Keywords: | Mercury chloride Omega-3 fatty acid Sialic acid Malondialdehyde Nitric oxide |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
