Cytotoxic activity of gypenosides and gynogenin against non-small cell lung carcinoma A549 cells |
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| Affiliation: | 1. Beijing Institute of Radiation Medicine, Beijing 100850, PR China;2. Tianjin University of Traditional Chinese Medicine, Tianjin 300193, PR China;3. Ovation Health Science and Technology Co. Ltd., ENN Group, Langfang 065001, PR China;1. Institute of Chinese Minority Traditional Medicine, Minzu University of China, Beijing 100081, China;2. Laboratory of Comparative Medicine, Guangdong Medical Laboratory Animal Center, Foshan, Guangdong 528248, China;1. Institute of Chinese Minority Traditional Medicine, Minzu University of China, Beijing 100081, China;2. Department of Breast Disease Prevention Center, Haidian Maternal and Child Health Hospital, Beijing 100080, China;1. School of Traditional Chinese Medicine, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China;2. Key Laboratory of Structure-Based Drug Design & Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China;3. Shenyang Pharmaceutical University, Shenyang 110016, People’s Republic of China;1. Department of Chemical and Pharmaceutical Engineering, College of Chemical Engineering, Huaqiao University, Xiamen 361021, Fujian province, PR China;2. Xiamen Hospital of Traditional Chinese Medicine, Xiamen 361009, Fujian province, PR China;3. Research Center of Natural Resources of Chinese Medicinal Materials and Ethnic Medicine, Jiangxi University of Traditional Chinese Medicine, Nanchang 330004, Jiangxi province, PR China;4. Institute of Pharmaceutical Engineering, Huaqiao University, Xiamen 361021, Fujian province, PR China;1. College of Food Science, Shenyang Agricultural University, Shenyang 110866, PR China;2. Department of Emergency Medicine, Laboratory of Rescue Center of Severe Wound and Trauma, PLA, General Hospital of Shenyang Military Command, Shenyang 110016, PR China;3. Key Laboratory of Food Nutrition and Safety, Ministry of Education, School of Food Engineering and Biotechnology, Tianjin University of Science and Technology, Tianjin 300457, PR China |
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| Abstract: | The activity of gypenosides and gynogenin of Gynostemma pentaphyllum against non-small cell lung carcinoma (NSCLC) A549 cells was investigated to identify the structural characteristics of gypenosides and gynogenin to have anti-NSCLC activity. Of the tested dammarane-type compounds, 20S-dammar-24-en-2α,3β,12β,20-tetrol showed the strongest activity against A549 cells. Based on the structure and cytotoxic activity relationships of gypenosides and gynogenin, the OH group in C-2, the connected sugar number and the configuration in C-20 were important for cytotoxic activity against A549 cells. |
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| Keywords: | Gypenoside Gynogenin Non-small cell lung carcinoma (NSCLC) A549 cell Saponins conversion |
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