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Newcastle Disease Virus-Vectored H7 and H5 Live Vaccines Protect Chickens from Challenge with H7N9 or H5N1 Avian Influenza Viruses |
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| Authors: | Qinfang Liu Ignacio Mena Jingjiao Ma Bhupinder Bawa Florian Krammer Young S Lyoo Yuekun Lang Igor Morozov Gusti Ngurah Mahardika Wenjun Ma Adolfo García-Sastre Juergen A Richt |
| Abstract: | Sporadic human infections by a novel H7N9 virus occurred over a large geographic region in China. In this study, we show that Newcastle disease virus (NDV)-vectored H7 (NDV-H7) and NDV-H5 vaccines are able to induce antibodies with high hemagglutination inhibition (HI) titers and completely protect chickens from challenge with the novel H7N9 or highly pathogenic H5N1 viruses, respectively. Notably, a baculovirus-expressed H7 protein failed to protect chickens from H7N9 virus infection. |
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