New titanocene derivatives with high antiproliferative activity against breast cancer cells |
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| Affiliation: | 1. Department of Pharmaceutical and Biomedical Sciences, University of Salerno, Italy;2. Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Italy;3. Department of Chemistry and Biology, University of Salerno, Italy;1. School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210093, China;2. Department of Organic Chemistry I, Faculty of Chemistry, University of the Basque Country UPV/EHU, Paseo Manuel Lardizábal 3, 20018 San Sebastián, Spain;3. Japan Synchrotron Radiation Research Institute, SPring-8, 1-1-1 Kouto, Sayo-gun, 679-5198 Sayo-cho, Hyogo, Japan;4. Department of Chemistry and Materials Science, Tokyo Institute of Technology, Ookayama 2, Meguro-ku, Tokyo 152-8551, Japan;5. National Institute of Advanced Industrial Science and Technology (AIST), Anagahora 2266-98, Shimoshidami, Moriyama, 463-8560 Nagoya, Aichi, Japan;6. IKERBASQUE, Basque Foundation for Science, María Díaz de Haro 3, 48013 Bilbao, Spain;7. Department of Chemistry, University of Turku, Vatselankatu 2, FIN-20014 Turku, Finland;8. Molecular Structure Analysis, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, D-69009 Heidelberg, Germany;1. A. N. Nesmeyanov Institute of Organoelement Compounds, Russian Academy of Sciences, 119991 Moscow, Russian Federation;2. N. D. Zelinsky Institute of Organic Chemistry, Russian Academy of Sciences, 119991 Moscow, Russian Federation;3. Moscow State High School No. 192, 119334 Moscow, Russian Federation;1. Analytical Science Group, Samsung Advanced Institute of Technology, Suwon, Gyeonggi-do 443-803, South Korea;2. GaN Device Group, Samsung Advanced Institute of Technology, Suwon, Gyeonggi-do 443-803, South Korea |
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| Abstract: | The synthesis and characterization of some new titanocene-complexes, having a ethenyl-phenoxide or a benzyl group as substituents of the cyclopentadienyl rings, are reported. The synthesized compounds have been evaluated for their cytotoxic potential against two human breast cancer cell lines, that is: MCF7 and SkBr3. Most of these compounds have shown significant cytotoxic effects, compared to cisplatin, in MTT-based cell tests. |
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| Keywords: | Metal-based anticancer drugs Titanocene compounds Breast cancer cells |
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