Sortase A inhibitory metabolites from the roots of Pulsatilla koreana |
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| Affiliation: | 1. Univ. Bourgogne Franche-Comté, AgroSupDijon, PAM, UMR A 02.102, F-21000 Dijon, France;2. Université Paris-Est, Anses, Laboratory for Food Safety, 94701 Maisons-Alfort, France;1. Department of Natural Products Chemistry, Shenyang Pharmaceutical University, Shenyang 110016, PR China;2. State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, PR China;3. Key Laboratory of Structure-Based Drug Design and Discovery, Ministry of Education, Shenyang Pharmaceutical University, Shenyang 110016, PR China;4. School of Pharmacy, Shenyang Pharmaceutical University, PR China;5. Harbin Pharmaceutical Group Co., LTD General Pharmaceutical Factory, Harbin 150046, PR China;6. Harbin Pharmaceutical Group Co., LTD Second Chinese Medicine Factory, Harbin 150078, PR China;7. China–Japan Research Institute of Medical Pharmaceutical Sciences, Shenyang Pharmaceutical University, PR China |
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| Abstract: | Three new lignans (3, 4, and 6) along with eight known lignans and phenyl propanoids were isolated from the dried roots of Pulsatilla koreana, an oriental folk medicine. Based upon the results of combined spectroscopic and chemical methods, the structures of new compounds were determined to be lignan glycosides. Included among the known compounds are three compounds (5, 7, and 8) isolated first time from this plant as well as two compounds (2 and 11) previously reported only as synthetic derivatives. These compounds significantly inhibited the action of Sortase A from Streptococcus mutans OMZ65, an isolate from human oral cavity. |
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| Keywords: | Lignans Phenyl propanoid Sortase A |
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