A Fraxinus excelsior L. seeds/fruits extract benefits glucose homeostasis and adiposity related markers in elderly overweight/obese subjects: A longitudinal,randomized, crossover,double-blind,placebo-controlled nutritional intervention study |
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| Institution: | 1. Department of Epidemiology, University of North Carolina, Chapel Hill, NC, USA;2. Department of Medicine, University of North Carolina, Chapel Hill, NC, USA;3. Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC, USA;1. Division of Nephrology & Hypertension, Department of Internal Medicine, University of Utah, 295 Chipeta Way, Salt Lake City, UT, USA;2. Department of Radiology and Imaging Science, Utah Center for Advanced Imaging Research, University of Utah, 729 Arapeen Dr., Salt Lake City, UT, USA;3. Medical Service, Veterans Affairs Salt Lake City Healthcare System, 500 Foothill Dr., 151N, Salt Lake City, UT, USA;4. Division of Plastic and Reconstructive Surgery, School of Medicine, University of Utah, 30 N. 1900 E. 3B400, Salt Lake City, UT, USA;1. Department of Medicine, University of Michigan, Ann Arbor, MI;2. Section of Cardiology, VA Eastern Colorado Health Care System, Denver, CO;3. Department of Medicine, University of Colorado Denver, CO;4. Colorado Cardiovascular Outcomes Research Group, Denver, CO;5. Department of Biostatistics and Informatics, University of Colorado Denver, Aurora, CO;6. Section of Cardiology, VA Boston Healthcare System, Departments of Medicine Brigham and Women''s Hospital and Harvard Medical School, Boston, MA;1. Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UT, United States;2. Department of Pharmacology/Toxicology, University of Utah College of Pharmacy, Salt Lake City, UT, United States |
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| Abstract: | PurposeThe aim of this study was to investigate the potential benefits of an extract obtained from seeds/fruits of an Oleaceae (Fraxinus excelsior L.) on glucose homeostasis and associated metabolic markers in non-diabetic overweight/obese subjects.Materials and methodsThis study was performed in 22 participants (50–80 years-old; BMI 31.0 kg/m2). The design was a longitudinal, randomized, crossover, double-blind, placebo-controlled 7-week nutritional intervention. The participants received daily 3 capsules each containing either 333 mg of an extract from Fraxinus excelsior L. seeds (Glucevia®) or placebo capsules (control) in a random order for 3 weeks with 1 week of washout between treatments. Moreover, they followed a balanced covert energy-restricted diet (?15% energy). All variables were measured at the beginning and at the end of each period.ResultsCompared to baseline, the administration of 1 g of Glucevia® for 3 weeks resulted in significantly lower incremental glucose area under the curve (?28.2%; p < 0.01), and significantly lower 2 h blood glucose values (?14%; p < 0.01) following an oral glucose tolerance test. No significant changes were found in the control group (?7.9% AUC, ?1.6% 2 h blood glucose). Furthermore, significant differences were found between responses in the control and Glucevia® groups with respect to serum fructosamine and plasma glucagon levels (p < 0.01 and p < 0.05, respectively). Interestingly, administration of Glucevia® significantly increased the adiponectin:leptin ratio (p < 0.05) and decreased fat mass (p < 0.01) compared to control (p < 0.05).ConclusionThe administration of an extract from Fraxinus excelsior L. seeds/fruits in combination with a moderate hypocaloric diet may be beneficial in metabolic disturbances linked to impaired glucose tolerance, obesity, insulin resistance and inflammatory status, specifically in older adults. |
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| Keywords: | Impaired glucose tolerance Diabetes Obesity Herbal medicine Fructosamine |
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