A near-infrared fluorescence dye for sensitive detection of hydrogen sulfide in serum |
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| Institution: | 1. College of Chemistry and Chemical Engineering, Bohai University, Jinzhou 121013, China;2. College of Food Science and Technology, Bohai University, National & Local Joint Engineering Research Center of Storage, Processing and Safety Control Technology for Fresh Agricultural and Aquatic Products, The Fresh Food Storage and Processing Technology Research Institute of Liaoning Provincial Universities, Jinzhou, 121013, China;3. College of Laboratory Medicine, Dalian Medical University, Dalian 116044, China |
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| Abstract: | Cy-Cl, a cationic near-infrared cyanine dye, readily reacts with hydrogen sulfide (H2S) via nucleophilic thiolation to give dose-dependent ‘turn-off’ fluorescence and colorimetric read-out, allowing selective detection of low levels of H2S in serum and imaging of mitochondrial H2S in living cells. |
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| Keywords: | Hydrogen sulfide Cyanine dye Serum Mitochondria Bioimaging Near-infrared |
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