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Exploring the Use of a Guanine-Rich Catalytic DNA for Sulfoxide Preparation |
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| Authors: | María A Dellafiore Javier M Montserrat Adolfo M Iribarren |
| Institution: | 1. Laboratorio de Química de Ácidos Nucleicos, INGEBI (CONICET), Ciudad Autónoma de Buenos Aires, Argentina.; 2. Instituto de Ciencias, Universidad Nacional de Gral. Sarmiento, Los Polvorines, Provincia de Buenos Aires, Argentina.; 3. Laboratorio de Biotransformaciones, Universidad Nacional de Quilmes, Bernal, Provincia de Buenos Aires, Argentina.; University of Pecs Medical School, HUNGARY, |
| Abstract: | A guanine-rich DNA oligonucleotide complexed with hemin was used to catalyze controlled oxygen transfer reactions to different sulfides for sulfoxide preparation in the presence of H2O2. Comparable activities were obtained when using fully modified L-DNA. In addition, oligonucleotide immobilization led to an active catalyst which could be successfully recovered and reused without loss of activity. |
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