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Hydrogel Nanofilaments via Core-Shell Electrospinning |
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| Authors: | Pawe? Nakielski Sylwia Paw?owska Filippo Pierini Wioletta Liwińska Patryk Hejduk Krzysztof Zembrzycki Ewelina Zabost Tomasz A Kowalewski |
| Institution: | 1. Department of Mechanics and Physics of Fluids, Institute of Fundamental Technological Research, Polish Academy of Sciences, Warsaw, Poland.; 2. Faculty of Chemistry, University of Warsaw, Warsaw, Poland.; University of California, San Diego, UNITED STATES, |
| Abstract: | Recent biomedical hydrogels applications require the development of nanostructures with controlled diameter and adjustable mechanical properties. Here we present a technique for the production of flexible nanofilaments to be used as drug carriers or in microfluidics, with deformability and elasticity resembling those of long DNA chains. The fabrication method is based on the core-shell electrospinning technique with core solution polymerisation post electrospinning. Produced from the nanofibers highly deformable hydrogel nanofilaments are characterised by their Brownian motion and bending dynamics. The evaluated mechanical properties are compared with AFM nanoindentation tests. |
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