Limonene inhibits methamphetamine-induced locomotor activity via regulation of 5-HT neuronal function and dopamine release |
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| Institution: | 1. Universidade Federal de Viçosa (UFV), Viçosa, MG, Brazil;2. Universidade Federal de Minas Gerais (UFMG), Belo Horizonte, MG, Brazil;1. School of Agriculture and Biology, Shanghai Jiao Tong University, 800 Dong Chuan Road, Shanghai, China;2. CAS Key Laboratory of Receptor Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences, 555 Zu Chong Zhi Road, Shanghai, China;1. Department of Rehabilitation Sciences, The Hong Kong Polytechnic University, Hong Kong, China;2. Department of Special Education and Counselling, The Education University of Hong Kong, Hong Kong, China;3. University Research Facility in Life Sciences, The Hong Kong Polytechnic University, Hong Kong, China;1. School of Agriculture and Biology, Shanghai Jiao Tong University, Shanghai, China;2. School of Design, Shanghai Jiao Tong University, Shanghai, China;1. Neuroscience Group of Antioquia, Cellular and Molecular Neurobiology Area - School of Medicine, SIU, University of Antioquia UdeA, Calle 70 No, 52-21, Medellin, Colombia;2. Grupo de Investigación en Sustancias Bioactivas, Facultad de Ciencias Farmacéuticas y Alimentarias, Universidad de Antioquía UdeA, Calle 70 No, 52-21, Medellin, Colombia |
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| Abstract: | Methamphetamine is a psychomotor stimulant that produces hyperlocomotion in rodents. Limonene (a cyclic terpene from citrus essential oils) has been reported to induce sedative effects. In this study, we demonstrated that limonene administration significantly inhibited serotonin (5-hydroxytryptamine, 5-HT)-induced head twitch response in mice. In rats, pretreatment with limonene decreased hyperlocomotion induced by methamphetamine injection. In addition, limonene reversed the increase in dopamine levels in the nucleus accumbens of rats given methamphetamine. These results suggest that limonene may inhibit stimulant-induced behavioral changes via regulating dopamine levels and 5-HT receptor function. |
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| Keywords: | Limonene Methamphetamine Drug addiction Dopamine 5-HT |
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