Selenium deficiency in children and adolescents nourished by parenteral nutrition and/or selenium-deficient enteral formula |
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| Institution: | 1. Department of Pediatric Gastroenterology, Nutrition and Endocrinology, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Osaka, Japan;2. Department of Nutrition, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Osaka, Japan;3. Department of Pediatric Surgery, Osaka Medical Center and Research Institute for Maternal and Child Health, Izumi, Osaka, Japan;1. Food Technology Department, Faculty of Engineering, BINUS University, Alam Sutra Campus, Tangerang, Indonesia;2. SEAMEO RECFON University of Indonesia, Salemba Raya 6, Jakarta, Indonesia;3. Faculty of Medicine, Indonesian Christian University, Jl. Mayjen Sutoyo Cawang, Jakarta 13630, Indonesia;4. Department of Public Health, Gunma University, Graduate School of Medicine, 39-22 Showa-machi 3-chome, Maebashi, Gunma 371-8511, Japan;1. Department of Food and Experimental Nutrition, Faculty of Pharmaceutical Sciences, University of São Paulo, São Paulo, Brazil;2. Department of Pathology, School of Veterinary Medicine and Animal Sciences, University of São Paulo, São Paulo, Brazil;1. Department of Human Nutrition, Seitoku University Graduate School, Chiba, Japan |
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| Abstract: | The authors analyzed serum selenium levels of 95 children and adolescents with intestinal dysfunction and/or neurological disabilities age range: 7 months–20 years; mean ± standard deviation (SD): 8.0 ± 5.3 years] who received parenteral nutrition (PN) and/or enteral nutrition (EN) with either reduced or no selenium doses for more than 3 months. Twenty-eight patients (29%) showed serum selenium levels below 4.0 μg/dL. Five patients whose serum selenium levels were below 2 μg/dL presented various clinical manifestations, including hair browning (n = 5), macrocythemia (n = 4), nail whitening (n = 3) and cardiac dysfunction (n = 1). None of these 5 patients were nourished through ordinary diets. Three of these patients were nourished through selenium-free enteral nutritional products, 1 through selenium-deficient PN and 1 through PN and a formula with reduced selenium. After selenium supplement therapy for 1 year, all 5 patients exhibited improvement in their serum selenium levels and clinical features of selenium deficiency. It is important to be cautious about secondary selenium deficiency in children and adolescents nourished only through EN/PN without an adequate dose of selenium. |
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| Keywords: | Selenium deficiency Child Parenteral nutrition Enteral nutrition Elemental diet |
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