Behavioral effects of developmental methylmercury drinking water exposure in rodents |
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Affiliation: | 1. Department of General Medicine, Yangpu Hospital of Tongji University, Department of General Practice of Tongji University, Shanghai 200090, China;2. Department of pediatrics, Soochow University Affiliated Children''s Hospital, Soochow University, Suzhou 215003, China;3. Department of Neurology, Affiliated Hospital of Xuzhou Medical University, Xuzhou 221002, China |
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Abstract: | Early methylmercury (MeHg) exposure can have long-lasting consequences likely arising from impaired developmental processes, the outcome of which has been exposed in several longitudinal studies of affected populations. Given the large number of newborns at an increased risk of learning disabilities associated with in utero MeHg exposure, it is important to study neurobehavioral alterations using ecologically valid and physiologically relevant models. This review highlights the benefits of using the MeHg drinking water exposure paradigm and outlines behavioral outcomes arising from this procedure in rodents. Combination treatments that exacerbate or ameliorate MeHg-induced effects, and possible molecular mechanisms underlying behavioral impairment are also discussed. |
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Keywords: | Mercury Developmental neurotoxicity Behavior Rodents Learning |
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