Fluctuation and relaxation analysis of monazomycin-induced conductance in black lipid membranes |
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| Authors: | L E Moore E Neher |
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| Institution: | (1) Abteilung molekularer Systemaufbau, Max-Planck-Institut für Biophysikalische Chemie (Karl-Friedrich Bonhoeffer Institut), D-34 Göttingen-Nikolausberg, Germany;(2) Department of Physiology, Case Western Reserve University, 44106 Cleveland, Ohio;(3) Present address: Department of Physiology and Biophysics, University of Texas Medical Branch, 77550 Galveston, Texas |
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| Abstract: | Summary Fluctuation and relaxation analyses were performed on monazomycin-induced conductance of lipid bilayer membranes. With both methods a slow (sec) and a fast (msec) current component are apparent; however, the amplitude of the slow, voltage-dependent process is greater than that of the fast component in the step relaxation experiment and less in the fluctuation experiment. The fluctuation analysis showed principally a rapid voltage-dependent process which appears to be related to the multistate character of the conducting channel. The experimental results are interpreted in terms of a simplified kinetic model which is used to calculate relaxation and noise amplitudes. |
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