New generation dopaminergic agents. Part 8: heterocyclic bioisosteres that exploit the 7-OH-2-(aminomethyl)chroman D(2) template |
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| Authors: | Mewshaw Richard E Zhao Rulin Shi Xiaojie Marquis Karen Brennan Julie A Mazandarani Hossein Coupet Joseph Andree Terrance H |
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| Affiliation: | Global Chemical Sciences Department, Wyeth-Ayerst Research Laboratories, PO Box 42528, Philadelphia, PA 19101-2528, USA. mewshar@war.wyeth.com |
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| Abstract: | Based on the 7-OH-2-(aminomethyl)chroman dopamine D(2) template (2) is described the preparation and resolution of two bioisosteric analogues. The benzimidazol-2-one derivative (6) had similar affinity to the known indolone derivative (4). |
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