Chemicomechanical transduction performed by enzymes activated by polymers |
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| Authors: | E Mizraji J Lin |
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| Affiliation: | 1. Departamento de Biofísica, Facultad de Medicina, Instituto de Ciencias Exactas, Facultad de Humanidades y Ciencias, Universidad de la República, Montevideo, Uruguay;2. Instituto de Física, Facultad de Ingeniería, Instituto de Ciencias Exactas, Facultad de Humanidades y Ciencias, Universidad de la República, Montevideo, Uruguay |
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| Abstract: | Kinetic models for the mode of action of processive and non-processive DNA-helicases are detailed. Fluxes at the steady state are analyzed, and the random walk of the enzymes on the DNA is studied in connection with the rate constants of the chemical reactions involved in the transformation of substrate to products. Finally, the constants of the kinetic model for the processive helicase are related to the parameters of an analogous viscoelastic model. |
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