Cloning and expression profile of human inorganic pyrophosphatase. |
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| Authors: | T A Fairchild G Patejunas |
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| Institution: | Evanston Northwestern Healthcare Research Institute, 2650 Ridge Avenue, Evanston, IL 60201, USA. |
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| Abstract: | We have cloned a 1.23 kb cDNA from a human heart library which encodes a 32 kDa protein that is 94% identical to bovine inorganic pyrophosphatase. The protein contains an aspartate-rich signature sequence that was previously identified in yeast and prokaryotic pyrophosphatases. Our clone detects a single band on Northern blots and is expressed at modest levels in all tissues examined. The cDNA shows linkage to markers on the long arm of chromosome 10. |
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