Application of a pig ligated intestinal loop model for early <Emphasis Type="Italic">Lawsonia intracellularis</Emphasis> infection |
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| Authors: | Torsten S Boutrup Kirsten Schauser Jørgen S Agerholm Tim K Jensen |
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| Institution: | 1.National Veterinary Institute,Technical University of Denmark,Copenhagen V,Denmark;2.Department of Veterinary Disease Biology, Faculty of Life Sciences,University of Copenhagen,Frederiksberg C,Denmark;3.Department of Basic Animal and Veterinary Sciences, Faculty of Life Sciences,University of Copenhagen,Frederiksberg C,Denmark |
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| Abstract: | Background Porcine proliferative enteropathy in pigs is caused by the obligate, intracellular bacterium Lawsonia intracellularis. In vitro studies have shown close bacterium-cell interaction followed by cellular uptake of the bacterium within 3 h post inoculation
(PI). However, knowledge of the initial in vivo interaction between porcine intestinal epithelium and the bacterium is limited. The aims of the present study were to evaluate
the usefulness of a ligated small intestinal loop model to study L. intracellularis infections and to obtain information on the very early L. intracellularis-enterocyte interactions. |
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