A comparison of in vitro anticancerous activity and mechanism of ethanolic extracts from different Ganoderma genus |
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| Authors: | Yueqin Zhou Xiaotong Yang Xuquan Li Huiqin Feng Ke Mi Qingyao Yang |
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| Institution: | 1. Institute of Microbiology and Immunology, Life and Environment Science College, Shanghai Normal University, Shanghai, 200234, China
2. 8th floor, Building No. 14th 100 Guilin Road, Shanghai, 200234, China
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| Abstract: | Five ethanolic extracts from the mycelia of Ganoderma lucidum,G.tsugae,G.oerstedii,G.subamboinense,and G.resinaceum were respectively studied on their anticancerous activities against leukemic HL-60 cell line in vitro.Results showed that all five extracts potently inhibited HL-60 proliferation.The extract from G.lucidum mycelia exerted the highest activity.Annexin V/PI bivariate flow cytometric analysis further revealed that the five extracts significantly induced early apoptosis in HL-60 cells.The results illustrate that not only G.lucidum but also other Ganoderma species can inhibit cancer cells,and their mechanisms are related to induction of apoptosis. |
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| Keywords: | Ganoderma anti-proliferation apoptosis HL-60 |
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