Static magnetic field effect on the arterial baroreflex-mediated control of microcirculation: implications for cardiovascular effects due to environmental magnetic fields |
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Authors: | Juraj Gmitrov |
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Institution: | (1) Department of Environmental Health, National Institute of Public Health, Tokyo 108, Japan;(2) Pro Vitae Hospital, Nemocnicna 33, Gelnica, 056 01, Slovak Republic |
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Abstract: | Increasing evidence suggests that time-varying and static magnetic fields in the environment might affect the cardiovascular
system. To explore the underlying physiology, the effect of static magnetic fields (SMFs) on the carotid baroreflex control
of microcirculation was studied. Twenty-four hemodynamic monitorings were performed in rabbits sedated by pentobarbital infusion
(5 mg/kg/h) during experiments that lasted 120 min. Mean femoral artery blood pressure, heart rate, and ear lobe skin microcirculatory
blood flow, measured by microphotoelectric plethysmogram (MPPG), were simultaneously recorded before and after a 40 min exposure
of the sinocarotid baroreceptors to Nd2–Fe14–B alloy magnets (n = 14) or sham magnets (n = 10, control series). The local SMF field was 350 mT, at the baroreceptors’ site. Arterial baroreflex sensitivity (BRS)
was estimated from heart rate/blood pressure response to intravenous bolus injections of nitroprusside and phenylephrine.
A significant positive correlation was found between the SMF-induced increase in BRS (ΔBRS = BRSafterSMF − BRSpriorSMF) and the increment in microvascular blood flow (ΔMPPG = MPPGafterSMF − MPPGpriorSMF) (r = 0.66, p < 0.009). The SMF probably modulated the arterial baroreflex-mediated microcirculatory control. This could represent one
possible mechanism how environmental magnetic fields act on the cardiovascular system, and a method how to complexly adjust
macro- and microcirculation with potential clinical implementation. |
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