Application of resequencing microarrays in microbial detection and characterization |
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Authors: | Leski Tomasz A Lin Baochuan Malanoski Anthony P Stenger David A |
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Institution: | Center for Bio/Molecular Science & Engineering, Naval Research Laboratory, SW, Washington, DC 20375, USA. tomasz.leski@nrl.navy.mil |
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Abstract: | Microarrays are powerful, highly parallel assays that are transforming microbiological diagnostics and research. The adaptation of microarray-based resequencing technology for microbial detection and characterization resulted in the development of a number assays that have unique advantages over other existing technologies. This technological platform seems to be especially useful for sensitive and high-resolution multiplexed diagnostics for clinical syndromes with similar symptoms, screening environmental samples for biothreat agents, as well as genotyping and whole-genome analysis of single pathogens. |
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