Inhibition of Toxoplasma gondii and Plasmodium falciparum infections in vitro by NSC3852, a redox active antiproliferative and tumor cell differentiation agent |
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| Authors: | Strobl Jeannine S Seibert Christopher W Li Yunbo Nagarkatti Rana Mitchell Sheila M Rosypal Alexa C Rathore Dharmendar Lindsay David S |
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| Institution: | Virginia College of Osteopathic Medicine, Virginia Tech Corporate Research Center, Blacksburg, Virginia 24060, USA. jstrobl@vcom.vt.edu |
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| Abstract: | We searched the National Cancer Institute (NCI) compound library for structures related to the antitumor quinoline NSC3852 (5-nitroso-8-quinolinol) and used a computer algorithm to predict the antiprotozoan activity for each of 13 structures. Half of these compounds inhibited Toxoplasma gondii tachyzoite propagation in human fibroblasts at
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