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Biotransformation of ergot alkaloids by plant cell cultures with high peroxidase activity |
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| Authors: | M. Ščigelová T. Macek A. Minghetti M. Macková P. Sedmera V. Přikrylová V. Křen |
| Affiliation: | (1) Institute of Microbiology, Academy of Sciences of the Czech Republic, Víde!["ncaron"]("/content/rr9423341917x663/xlarge328.gif") ská 1083, 4 Prague, Czech Republic;(2) Institute of Organic Chemistry and Biochemistry, Academy of Sciences of the Czech Republic, Flemingovo nám!["ecaron"]("/content/rr9423341917x663/xlarge283.gif") stí 2, 6 Prague, Czech Republic;(3) Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro 6, I-40126 Bologna, Italy;(4) Department of Biochemistry and Microbiology, Institute of Chemical Technology, Technická 3, 6 Prague, Czech Republic |
| Abstract: | Ergot alkaloids agroclavine and elymoclavine have been modified using plant cell cultures exhibiting high peroxidase activity. Setoclavine and isosetoclavine have been isolated from media after transformation of agroclavine on a semipreparative scale. 10-Hydroxyelymoclavine resulted from similar treatment of elymoclavine. |
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