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Molecular motors: Dynein's gearbox |
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| Authors: | Cross R A |
| Affiliation: | Molecular Motors Group, Marie Curie Research Institute, The Chart, Oxted, Surrey RH8 0TL, UK. r.cross@mcri.ac.uk |
| Abstract: | A new optical trapping study shows that the stepsize of cytoplasmic dynein varies according to the applied force, suggesting that this motor can change gear. Complementary biochemical kinetic work on yeast dynein mutants hints at the allosteric mechanisms involved. |
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