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Chimeric cytochromes P450 engineered by domain swapping and random mutagenesis for producing human metabolites of drugs |
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| Authors: | Ji‐Yeon Kang Sang Hoon Ryu Sun‐Ha Park Gun Su Cha Dong‐Hyun Kim Keon‐Hee Kim Austin W Hong Taeho Ahn Jae‐Gu Pan Young Hee Joung Hyung‐Sik Kang Chul‐Ho Yun |
| Institution: | 1. School of Biological Sciences and Technology, Chonnam National University, Gwangju, Republic of Korea;2. Wayne Hills High School, Wayne, New Jersey;3. Department of Biochemistry, College of Veterinary Medicine, Chonnam National University, Gwangju, Republic of Korea;4. Superbacteria Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Daejon, Republic of Korea;5. +82‐62‐530‐2194+82‐62‐530‐2199 |
| Abstract: | |
| Keywords: | biocatalyst bacterial CYP102A1 domain swapping chimeric enzyme human drug metabolite statin drug |