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Transcriptome dynamics of transgene amplification in Chinese hamster ovary cells |
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| Authors: | Nandita Vishwanathan Huong Le Nitya M. Jacob Yung‐Shyeng Tsao Sze‐Wai Ng Bernard Loo Zhong Liu Anne Kantardjieff Wei‐Shou Hu |
| Affiliation: | 1. Department of Chemical Engineering and Materials Science, University of Minnesota, Minneapolis, Minnesota;2. Bioprocess Development, Merck & Co., Union, New Jersey;3. Bioprocessing Technology Institute, Singapore, Singapore;4. +1‐612‐625‐0546+1‐612‐626‐7246 |
| Abstract: | |
| Keywords: | gene amplification dihydrofolate reductase (DHFR) methotrexate (MTX) selection hyper‐productivity Chinese Hamster Ovary (CHO) cells mammalian cell culture |