Improved linkage map and thirty new microsatellite markers for rat Chromosome 10 |
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| Authors: | Oksana I Dukhanina Vladimir E Sverdlov Barbara Hoebee John P Rapp |
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| Institution: | (1) Department of Physiology and Molecular Medicine, Medical College of Ohio, 3035 Arlington Avenue, Toledo, Ohio 43614-5804, USA, US;(2) National Institute of Public Health and the Environment, Laboratory of Health Effects Research, Bilthoven 3720 BA, The Netherlands, NL |
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| Abstract: | An improved linkage map for rat Chromosome (Chr) 10 with two F2 populations was constructed. Thirty new microsatellite markers were generated from a Chr 10-specific, small-insert genomic
library and mapped to rat Chr 10. Among them were the rat homologs for the mouse gene for light and heavy chains of myeloperoxidase
and human neurofibromatosis 1. Eight newly generated markers (D10Mco62, D10Mco63, D10Mco64, D10Mco65, D10Mco67, D10Mco68, D10Mco70, and D10Mco74) were mapped to the region of the rat Chr 10 blood pressure QTL. The availability of such markers may be instrumental in
the search for genes responsible for the hypertension.
Received: 13 July 1998 / Accepted: 9 September 1998 |
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