Analysis of Human T-Cell Leukemia Virus Type 1 Particles by Using Cryo-Electron Tomography |
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| Authors: | Sheng Cao José O. Maldonado Iwen F. Grigsby Louis M. Mansky Wei Zhang |
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| Affiliation: | aInstitute for Molecular Virology, University of Minnesota, Minneapolis, Minnesota, USA;bDepartment of Diagnostic and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, Minnesota, USA;cDepartment of Microbiology, University of Minnesota, Minneapolis, Minnesota, USA;dCharacterization Facility, College of Science and Engineering, University of Minnesota, Minneapolis, Minnesota, USA |
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| Abstract: | The particle structure of human T-cell leukemia virus type 1 (HTLV-1) is poorly characterized. Here, we have used cryo-electron tomography to analyze HTLV-1 particle morphology. Particles produced from MT-2 cells were polymorphic, roughly spherical, and varied in size. Capsid cores, when present, were typically poorly defined polyhedral structures with at least one curved region contacting the inner face of the viral membrane. Most of the particles observed lacked a defined capsid core, which likely impacts HTLV-1 particle infectivity. |
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