A new phenanthrene with a spirolactone from Dendrobium chrysanthum and its anti-inflammatory activities |
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| Authors: | Yang Li Qin Lin-Hua Bligh S W Annie Bashall A Zhang Chao-Feng Zhang Mian Wang Zheng-Tao Xu Luo-Shan |
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| Affiliation: | Key Laboratory of Standardization of Chinese Medicines of Ministry of Education, Institute of Chinese Materia Medica, Shanghai University of Traditional Chinese Medicine, 1200 Cailun Road, Zhangjiang Hi-tech Park, Shanghai 201203, PR China. |
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| Abstract: | Investigation of phenolic patterns from the stems of Dendrobium chrysanthum by HPLC-PDA-MS has led to the isolation of a new phenanthrene derivative with a spirolactone ring, dendrochrysanene (1), that proved to suppress the mRNA level of TNF-alpha, IL8, IL10, and iNOS in murine peritoneal macrophages. The structure of 1 was characterized on the basis of various NMR (1H, 13C, 1H-1H COSY, HMQC, and HMBC), mass spectrometry, and X-ray crystal diffraction data. |
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