Disruption of occludin function in polarized epithelial cells activates the extrinsic pathway of apoptosis leading to cell extrusion without loss of transepithelial resistance期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

Disruption of occludin function in polarized epithelial cells activates the extrinsic pathway of apoptosis leading to cell extrusion without loss of transepithelial resistance

Authors:	Neal E Beeman Heidi K Baumgartner Patricia G Webb Jerome B Schaack Margaret C Neville

Affiliation:	(1) Department of Physiology and Biophysics, School of Medicine, University of Colorado Denver, 80045 Aurora, CO, USA;(2) Department of Microbiology, School of Medicine, University of Colorado Denver, 80045 Aurora, CO, USA;(3) Program in Molecular Biology, School of Medicine, University of Colorado Denver, 80045 Aurora, CO, USA;(4) Department of Obstetrics and Gynecology, School of Medicine, University of Colorado Denver, 80045 Aurora, CO, USA;(5) Dept of Pathology, Emory University, Whitehead Building, Rm 111, 615 Michael St, 30322 Atlanta, Georgia, USA

Abstract:	Background Occludin is a tetraspanin protein normally localized to tight junctions. The protein interacts with a variety of pathogens including viruses and bacteria, an interaction that sometimes leads to its extrajunctional localization.

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