Disruption of occludin function in polarized epithelial cells activates the extrinsic pathway of apoptosis leading to cell extrusion without loss of transepithelial resistance期刊界 All Journals 搜尽天下杂志传播学术成果专业期刊搜索期刊信息化学术搜索

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Disruption of occludin function in polarized epithelial cells activates the extrinsic pathway of apoptosis leading to cell extrusion without loss of transepithelial resistance

Authors:	Neal E Beeman Heidi K Baumgartner Patricia G Webb Jerome B Schaack and Margaret C Neville

Institution:	(1) Department of Physiology and Biophysics, School of Medicine, University of Colorado Denver, 80045 Aurora, CO, USA;(2) Department of Microbiology, School of Medicine, University of Colorado Denver, 80045 Aurora, CO, USA;(3) Program in Molecular Biology, School of Medicine, University of Colorado Denver, 80045 Aurora, CO, USA;(4) Department of Obstetrics and Gynecology, School of Medicine, University of Colorado Denver, 80045 Aurora, CO, USA;(5) Dept of Pathology, Emory University, Whitehead Building, Rm 111, 615 Michael St, 30322 Atlanta, Georgia, USA

Abstract:	Background Occludin is a tetraspanin protein normally localized to tight junctions. The protein interacts with a variety of pathogens including viruses and bacteria, an interaction that sometimes leads to its extrajunctional localization.

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