Analysis of the role of COP9 Signalosome (CSN) subunits in K562; the first link between CSN and autophagy |
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| Authors: | Claire Pearce Rachel E Hayden Christopher M Bunce Farhat L Khanim |
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| Affiliation: | (1) College of Life and Environmental Sciences, School of Biosciences, University of Birmingham, Edgbaston, Birmingham, B15 2TT, UK |
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| Abstract: | Background The COP9/signalosome (CSN) is a highly conserved eight subunit complex that, by deneddylating cullins in cullin-based E3 ubiquitin ligases, regulates protein degradation. Although studied in model human cell lines such as HeLa, very little is known about the role of the CSN in haemopoietic cells. |
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