Hybrid of Monkey and Human Adenoviruses |
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Authors: | A. D. Altstein N. N. Dodonova N. N. Vassilyeva E. M. Tsetlin |
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Affiliation: | L. A. Tarassevich State Control Institute for Medical Biological Preparations, Moscow, USSR |
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Abstract: | Following joint replication of monkey SA7 adenovirus (C8 strain) and human adenovirus type 2 in green monkey kidney tissue culture, a virus possessing the properties of a hybrid was obtained. It was designated Ad2C8. Ad2C8 preparations contained two types of viral particles: human adenovirus type 2, and hybrid particles. The hybrid virions multiplied in green monkey kidney cells in the presence of human adenovirus types 1, 2, and 3, but not 3 and 7, and acquired the capsid of the helper adenovirus. The hybrid can serve as a helper for human adenoviruses. It can apparently induce T antigen of the C8 virus but, in contrast to the latter, does not induce tumors in hamsters. |
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