Regulation of human placental deoxyguanosine kinase by nucleotides |
| |
| Authors: | Y Yamada H Goto N Ogasawara |
| |
| Affiliation: | Department of Biochemistry, Institute for Development Research, Aichi Prefectural Colony, Kasugai, Aichi 480-03, Japan |
| |
| Abstract: | The activity of deoxyguanosine kinase purified from human placenta was regulated by various nucleotides. dTTP, an activator, only increased the Vmax value of the enzyme. The feedback inhibition by dGTP, dGDP and dGMP were competitive with respect to deoxyguanosine. Both the activation by dTTP and the inhibition by dGTP were reversible. |
| |
| Keywords: | Deoxyguanosine kinase Human placenta Regulation dTTP dGTP |
| 本文献已被 ScienceDirect 等数据库收录！ |
|
