The suppressive effect of beta-glucan on the production of tumor necrosis factor-alpha in BV2 microglial cells |
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Authors: | Jung Kyung Hee Kim Mi-Ja Ha Eunyoung Kim Hye Kyung Kim Young Ock Kang Soon Ah Chung Joo-Ho Yim Sung-Vin |
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Institution: | Department of Pharmacology, School of Medicine, Kyung Hee University, Seoul, Korea. |
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Abstract: | Beta-glucan was recently shown to have the ability to enhance and stimulate the immune system in humans, but little is known about its the anti-inflammatory effects. We investigated the effect of beta-glucan on the production of tumor necrosis factor-alpha (TNF-alpha), a major pro-inflammatory mediator, in lipopolysaccharide (LPS)-stimulated BV2 microglial cells. beta-Glucan decreased the production and expression of TNF-alpha. In addition, it blocked LPS-stimulated activation of nuclear factor kappa B (NF-kappaB). Hence beta-glucan might suppress LPS-stimulated TNF-alpha production by inhibiting NF-kappaB in BV2 microglial cells. |
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