Personalized application of three different concentrations of iodinated contrast media in coronary computed tomography angiography |
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| Authors: | Meng Zhang Panpan Hao Chenyu Jiang Guoxiang Hao Bin Li Peixin Hu Qingjie Chen Yuguo Chen Aifeng Zhang Yun Zhang Yanping Liu |
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| Affiliation: | 1. The Key Laboratory of Cardiovascular Remodeling and Function Research, Chinese Ministry of Education, Chinese National Health Commission and Chinese Academy of Medical Sciences, The State and Shandong Province Joint Key Laboratory of Translational Cardiovascular Medicine, Department of Cardiology, Qilu Hospital of Shandong University, Jinan, China;2. Shandong Institute of Innovation, Suzhou Institute of Biomedical Engineering and Technology Affiliated with Chinese Academy of Sciences, Jinan, China;3. Department of Clinical Pharmacy, School of Pharmaceutical Sciences of Shandong University, Jinan, China;4. Jinan Central Hospital Affiliated with Shandong First Medical University and Shandong University, Jinan, China;5. First Hospital Affiliated with Xinjiang Medical University, Urumqi, China;6. Department of Nephrology, Brigham and Women's Hospital Affiliated with Harvard Medical School, Boston, Massachusetts;7. Department of Radiology, Qilu Hospital of Shandong University, Jinan, China |
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| Abstract: | No study has evaluated the impact of different iodinated contrast media on coronary contrast enhancement, using an injection protocol according to body surface area (BSA). Thus, the present study aimed to examine the usefulness and safety of personalized application of different iodine concentrations of contrast media in coronary computed tomographic (CT) angiography with a 2nd dual-source CT scanner in eliminating differences in coronary contrast enhancement based on a BSA-adapted injection protocol of contrast media. A total of 270 enrolled participants were randomly assigned to three groups: ioversol 320, ioversol 350 and iopromide 370 (n = 90 per group). The three groups were administered contrast media at a BSA-adjusted volume and flow rate with a fixed injection time of 15 seconds, and they subsequently received a 30-mL saline flush. All patients were scanned with a prospective electrocardiogram-gated protocol in a craniocaudal direction using a second-generation 128-slice dual-source CT system. The three iodinated contrast media used in coronary CT angiography exhibited similar diagnostic quality and safety. No significant differences were found in the contrast enhancement degrees, image quality scores, radiation doses and incidences of adverse effects among the three groups. The three contrast media used in coronary CT angiography with 320, 350 and 370 mg/mL iodine, respectively, have comparable diagnostic quality and safety. However, more large-scale, multinational, multi-centre and prospective trials are warranted. |
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| Keywords: | body surface area contrast media coronary CT angiography |
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