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Evolution of SIVsm in humanized mice towards HIV-2 |
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| Authors: | James Curlin Kimberly Schmitt Leila Remling-Mulder Ryan Moriarty Kelly Goff Shelby O’Connor Mark Stenglein Preston Marx Ramesh Akkina |
| Institution: | 1. Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA;2. University of Wisconsin School of Medicine and Public Health, Madison, WI, USA;3. Department of Tropical Medicine, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA;4. Department of Tropical Medicine, Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA
Tulane National Primate Research Center, Covington, LA, USA |
| Abstract: | Through the accumulation of adaptive mutations, HIV-2 originated from SIVsm. To identify these evolutionary changes, a humanized mouse model recapitulated the process that likely enabled this cross-species transmission event. Various adaptive mutations arose, as well as increased virulence and CD4+ T-cell decline as the virus was passaged in humanized mice. |
| Keywords: | cross-species SIV transmission HIV-2 viral evolution hu-HSC mice for viral cross-species jump SIVsm evolution towards HIV-2 SIVsm infection in humanized mice Sooty Mangabeys |