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Mimicking SIV chimpanzee viral evolution toward HIV-1 during cross-species transmission |
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| Authors: | Kimberly Schmitt James Curlin Leila Remling-Mulder Ryan Moriarty Kelly Goff Shelby O’Connor Mark Stenglein Preston Marx Ramesh Akkina |
| Affiliation: | 1. Department of Microbiology, Immunology and Pathology, Colorado State University, Fort Collins, CO, USA;2. University of Wisconsin School of Medicine and Public Health, Madison, WI, USA;3. Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA;4. Tulane University School of Public Health and Tropical Medicine, New Orleans, LA, USA Tulane National Primate Research Center, Covington, LA, USA |
| Abstract: | HIV-1 evolved from SIV during cross-species transmission events, though viral genetic changes are not well understood. Here, we studied the evolution of SIVcpzLB715 into HIV-1 Group M using humanized mice. High viral loads, rapid CD4+ T-cell decline, and non-synonymous substitutions were identified throughout the viral genome suggesting viral adaptation. |
| Keywords: | Cross-species SIV transmission HIV-1 viral evolution from SIV hu-HSC mice for cross-species viral transmission SIV chimpanzee evolution toward HIV-1 SIVcpz infection in humanized mice |