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Identification of compounds inhibiting prion replication and toxicity by removing PrPC from the cell surface
Authors:Silvia Biggi  Michael Pancher  Claudia Stincardini  Silvia Luotti  Tania Massignan  Andrea Dalle Vedove  Andrea Astolfi  Pamela Gatto  Graziano Lolli  Maria Letizia Barreca  Valentina Bonetto  Valentina Adami  Emiliano Biasini
Affiliation:1. Dulbecco Telethon Laboratory of Prions and Amyloids, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Trento, Italy;2. HTS Core Facility, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Trento, Italy;3. Department of Molecular Biochemistry and Pharmacology, Istituto di Ricerche Farmacologiche Mario Negri IRCCS, Milan, Italy;4. Laboratory of Protein Crystallography and Structure-Based Drug Design, Department of Cellular, Computational and Integrative Biology (CIBIO), University of Trento, Trento, Italy;5. Department of Pharmaceutical Sciences, University of Perugia, Perugia, Italy
Abstract:
Keywords:hematein  high-content screening  neurodegeneration  prion diseases  prions  PrPC
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